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Creative Biolabs is the leading custom service provider with extensive experience in various antibody production and engineering fields.
Creative Biolabs
Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (IgG(L)-scFv) | Creative Biolabs
Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (IgG(L)-scFv) is formed by an IgG and two scFv moieties. The scFv fragments from an anti-DNMT1 antibody are fused to the C terminus of an anti-SHH IgG light (L) chains, or vice versa. It is a type of appended IgGs, which is bispecific and tetravalent (2+2 antigen-binding valency). This BsAb can bind two factors simultaneously, block Hedgehog binding to PTCH, downregulate of DNMT1 and block DNA methylation. It is designed for the research of Hormone refractory breast cancer (HRBC) therapy.
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