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Creative Biolabs is the leading custom service provider with extensive experience in various antibody production and engineering fields.
Creative Biolabs
Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Fv-IgG) | Creative Biolabs
Recombinant Anti-Ad fiber knob x Anti-EPCAM Bispecific Antibody (Fv-IgG) is an appended IgG format, which has 2+2 antigen-binding valency. This dual variable domain IgG is generated by appending variable domains of an anti-Ad fiber knob IgG with similar domains from an anti-EPCAM antibody via short peptide linkers, or vice versa. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing.
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