Companies / Amerigo Scientific / Recombinant Human HER4 (N-GST tag)
Amerigo Scientific

Recombinant Human HER4 (N-GST tag) | Amerigo Scientific

HER4 or ERBB4 is a transmembrane receptor tyrosine kinase that belongs to epidermal growth factor receptor family. Through its interaction with its activating ligand heregulin, HER4 can regulate proliferation and differentiation of cells. HER4 ectodomain is cleaved by a metalloprotease, gamma-secretase that releases the HER4 intracellular domain from the membrane and facilitates its translocation to the nucleus. The kinase activity of HER4 is both necessary and sufficient to trigger an antiproliferative response in human breast cancer cells. Increased expression of HER4 has been detected in various cancers and this usually correlates to better survival.

Reviews


No reviews yet

ABOUT THE COMPANY

Amerigo Scientific is a distribution company focused on providing critical products and services to the biomedical and life science research communities. Although a new company, Amerigo Scientific's founder has had more than 20 years of rich experience in the biomedical and biochemical fields, and has established close contacts with key personnel in...
READ MORE