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A major goal of molecular diagnostics is to find a sensitive and specific means for detecting and quantifying DNA fragments from rare cancer cells (by virtue of an identifying somatic mutatio...
Hepatocellular carcinoma (HCC) is a significant contributor to cancer-related mortality in the United States and worldwide. Current treatments are largely ineffective: single agent and combin...
This presentation discusses the advantages and disadvantages of robotic surgery. The initial goals for a robotic prostatectomy will be discussed as well as patient expectations and outcomes.&...
Micro RNAs (miRNAs) are small, naturally-occurring non-coding ribonucleic acids with sizes between 18 and 40 nucleotides (nts) that have been demonstrated to play a significant role in the re...
The management of prostate cancer (PCa) continues to evolve and does so at a rapid rate. Research and technological developments continue to refine our definitions and management of this comp...
The Warburg effect or aerobic glycolysis is a well-known cancer metabolism phenomenon and serves as an established test for tumor detection with FDG-PET scanning technology. Cancer cells swit...
The burgeoning area of molecular risk assessment (gene expression profiling and/or proteomic tests) in the diagnosis and treatment of prostate cancer is rapidly illuminating how clinicians mi...
Using the NSGTM mouse (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ), JAX In Vivo Pharmacology Services has combined the human CD34+ hematopoietic stem cell engrafted NSGTM (hu-CD34 NSGTM) with human pat...
The landscape for treatment options in metastatic castration resistant prostate cancer has changed dramatically since 2010. There have been more therapies approved since 2010 than in the prio...
We have been developing methods to target drugs specifically to pathologic cells, thereby avoiding collateral toxicity to healthy cells. In the case of cancer, we have exploited up-regulation...
The genome determines changes of the transcription profile upon environmental changes and finally determines how a cell reacts. A comparative genome and transcriptome analysis of the same sam...
LEARNING OBJECTIVES:1. Enhanced audience understanding regarding the controversy surrounding prostate cancer screening using the PSA blood test and use of the American Uro...
To learn more about Gene Editing watch “Webinar: CRISPR-Cas9 Gene Editing with Synthetic RNA – from start to finish!”
Attendees will learn:
the importance of ...
DATE: September 23, 2015TIME: 9AM Pacific time, 12PM Eastern timeThe majority of emerging diseases are infections with viruses that jump species barriers from wildlife or domestic animals to ...
DATE: Sept 22, 2015TIME: 9:00am PDT, 12:00PM EDTHeart failure is a complex syndrome and affects over 5.1 Million Americans today with approximately 500,000 new heart failure cases each year. ...
Surface plasmon resonance (SPR) is a sensitive, label-free technique that detects mass changes due to biomolecular interactions on a surface. This versatile method has been used to evaluate t...
Despite recent developments in hyphenated techniques and column technology, analysis of small polar analytes (small organic acids, phosphorylated sugars, and underivatized amino acids) remain...
DATE: September 17, 2015TIME: 7:30AM PDT, 10:30AM EDTAs technology advances and globalization develops, our way of life has become more dependent on energy sources to power our everyday activ...
Structure-based drug discovery requires expert designers, aided by software that integrates 3D structure visualization and molecular editing with multivariate experimentaland calculated prope...
Synthetic biology—the design and construction of new biological parts, devices, and systems, and the redesign of natural biological systems for useful purposes—is contributing sus...
In this interactive session, Derek Lowe will be taking questions from the audience in an informal discussion on his work in drug discovery, and his take on the current pharma landscape. Moder...
Among the frontier challenges in chemistry in the 21st century are the interconnected goals of increasing control of chemical reactivity while synthesizing and diversifying complex molecules ...
Nanotechnology, the engineering and manufacture of materials at the atomic and molecular scale, is used at BIND Therapeutics to develop novel Accurin™ nanomedicines that utilize cytotoxic age...
Humans are colonized by vast numbers of symbiotic microorganisms whose metabolisms are inextricably intertwined with our own. To understand how chemical transformations performed by the human...
The process by which observations in the laboratory or the clinic are transformed into demonstrably useful interventions that tangibly improve human health is frequently termed "translation."...
Learning Objectives for this presentation -
(1) Understand how human genetics can contribute to drug discovery and development.
(2) Understand the role of biomarkers and clinical proof-...
Recent evidence demonstrating the importance of structural complexity in advancing compounds to the clinic points to the need for enhancing small molecule screening collections with sp3-rich ...
A major goal of molecular diagnostics is to find a sensitive and specific means for detecting and quantifying DNA fragments from rare cancer cells (by virtue of an identifying somatic mutatio...
