Supporting drug development for advanced therapies with high-quality RNA analysis: The critical role of sampling and pre-analytics

In advanced therapy development, blood samples are essential to gain molecular insights. RNA and biomarker profiles are highly sensitive to preanalytical variables—such as collection, transport, storage, and processing. Accurate RNA analysis depends not just on quantification, but on every step leading up to it—starting with careful sample collection and pre-analytical handling. Each stage can significantly affect both biomarker integrity and the in vivo gene expression profile. Standardizing the pre-analytical workflow ensures high-quality RNA for reliable results, aiding advanced therapy development.

This webinar explores how pre-analytical variables—especially during sample storage and transport—can impact blood-based RNA analysis results. We emphasize the importance of standardized protocols for sample collection, stabilization, and RNA extraction to preserve RNA quality and quantity.

We demonstrate how compromised RNA integrity can alter gene expression readouts and affect conclusions for downstream processes. Understanding and controlling pre-analytical steps is critical for ensuring reliable assay performance and meaningful biological data, ultimately supporting the development of advanced therapeutics.