Name: "Adnectin (EGFR Receptor) h(CD28-CD3_) Ligand-based CAR, pCDCAR1"
Availability: InStock

"Adnectin (EGFR Receptor) h(CD28-CD3_) Ligand-based CAR, pCDCAR1" | Creative Biolabs

Adnectin is derived from the 10th type III domain of human fibronectin (10Fn3). The 10Fn3 domain interacts with integrins and belongs to the immunoglobulin superfamily. One of the target membrane surface receptors to direct adnectin-CAR-T cells is the epithelial growth factor receptor (EGFR). It is one of the most suitable candidates targeted in cancer therapies, since it is overexpressed in several tumors such as breast, lung, and head and neck.
Creative Biolabs provides a second-generation CAR vector which is designed using IL-11 peptide/protein as the extracellular domain. The vector is constructed for the engineering of T cells to target Human IL-12R_.