Name: "IL-11 (IL-11R_ Receptor) h(CD28-CD3_) Ligand-based CAR, pCDCAR1"
Availability: InStock

"IL-11 (IL-11R_ Receptor) h(CD28-CD3_) Ligand-based CAR, pCDCAR1" | Creative Biolabs

The IL-11/IL-11R_ signaling pathway is involved in several biological activities, and it is supposed to induce an antiapoptotic effect via STAT3 activation (42, 43). It has been shown that human IL-11R_ is overexpressed in several types of cancer, including osteosarcoma (OS) and lung-associated metastases.
Creative Biolabs provides a second-generation CAR vector which is designed using IL-11 peptide/protein as the extracellular domain. The vector is constructed for the engineering of T cells to target Human IL-11R_.