Name: "Anti-GD3 (KM641) h(CD28-CD3_) CAR, pMMLV"
Availability: InStock

"Anti-GD3 (KM641) h(CD28-CD3_) CAR, pMMLV" | Creative Biolabs

Recombinant Moloney murine leukemia virus (MMLV) retroviral vectors serve as efficient viral vector tools for introducing genes permanently into a wide variety of dividing cells, and provide an alternative to modify primary T cells. Creative biolabs has developed retroviral CAR vector pMMLV GD3 (KM641) h(28_), which is constructed for the engineering of T cells to target human GD3. The T cells are genetically modified through transduction with a retroviral vector expressing scFv of anti-GD3 antibody linked to a CD28 transmembrane domain and CD3-zeta signaling domains. And the vector product was designed for the treatment of solid tumors such as melanomas , neuroblastoma, and liquid tumors such as T - cell acute lymphoblastic leukemia.