Inotuzumab (brand name Besponsa) is a monoclonal antibody used in the treatment of certain types of leukemia. Inotuzumab specifically targets CD22, a protein expressed on the surface of B-cell lymphoblasts in acute lymphoblastic leukemia (ALL) and other B-cell malignancies. By binding to CD22, Inotuzumab interferes with cell signaling pathways involved in cell growth and survival, ultimately leading to cell death. Inotuzumab is indicated for the treatment of adults with relapsed or refractory CD22-positive B-cell precursor ALL. It is used when other treatments have not been effective or when the disease has returned after previous treatment.